A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency
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چکیده
Background: Clonidine is α2 adrenergic receptor agonist with detrimental effect on locus coeruleus. It is considered as one of the detoxification drugs in order to reduce opiate withdrawal syndrome. We conducted this study in order to assess clonidine effect on withdrawal symptoms and signs. Materials and methods This double blind, clinical trial, single centered study was conducted among 104 male inpatient heroin dependent patients in Psychiatric Center. They were selected via convenient sampling method. Subsequently, they were divided randomly into two matched groups: trial–control (clonidine –placebo) groups. Withdrawal symptoms and signs based on DSM–5 were compared in groups. Results: In 14 day detoxification period (in 7 th and 14 th day examination), the effect of clonidine on craving and agitation (p < 0.01) was significant. With respect to other symptoms and signs, clonidine was not effective prominently. Discussion: Due to different results compared to previous studies in this area. Clonidine use with respect to opioid withdrawal syndrome needs further evaluation or may need to revise.
منابع مشابه
Impact of Oral Clonidine on Duration of Opioid and Benzodiazepine Use in Mechanically Ventilated Children: A Randomized, Double-Blind, Placebo-Controlled Study
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متن کاملImpact of Oral Clonidine on Duration of Opioid and Benzodiazepine Use in Mechanically Ventilated Children: A Randomized, Double-Blind, Placebo-Controlled Study
Objective: Long term use of opioids and benzodiazepines are associated with important untoward effects. The α2 adrenergic agonist clonidine has sedative effects. Our goal was to study clonidine addition to total doses of fentanyl and midazolam and duration of ventilation in pediatric ICU (PICU). Methods: This randomized, double-blind, placebo-controlled trial was conducted in PICU of Mofi...
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متن کاملبا کلوفن وکلونیدین در سمزدایی مواد افیونی
Abstract Objectives: This study was conducted to evaluate the efficacy and side effects of baclofen and clonidine treatments in opioid detoxification. Method: 66 subjects from an outpatient setting diagnosed with opium dependency (based on DSM-IV) took part in a double blind study. Randomly 32 and 34 subjects were assigned to take respectively baclofen and clonidine for 14 days. Findings: Both ...
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تاریخ انتشار 2017